|
T8348 |
Phentolamine
|
|
Adrenergic Receptor
|
|
Phentolamine mesylate is an alpha-1 and alpha-2 selective adrenergic receptor antagonist |
|
T7127 |
DC260126
|
|
Apoptosis
,
GPR
|
|
DC260126 is a small-molecule antagonist of FFA1 (GPR40) |
|
T3171 |
GSK137647A
|
GSK 137647 |
GPR
|
|
GSK137647A (GSK 137647) is a selective FFA4 agonist. |
|
T21623 |
AS1269574
|
AS 1269574 |
GPR
,
TRP/TRPV Channel
|
|
AS1269574 is a potent, orally available GPR119 agonist. AS1269574(AS 1269574) has the potential for the research of type 2 diabetes. |
|
T40187 |
GNF2133
|
|
DYRK
|
|
GNF2133 is an effective and selective inhibitor of DYRK1A with IC50s of 6.2 nM. GNF2133 can be used in studies about type 1 diabetes. |
|
T15247 |
ESI-05
|
NSC 116966 |
cAMP
|
|
ESI-05 (NSC-116966) is a specific EPAC2 (exchange protein directly activated by cAMP 2) antagonist (IC50: 0.4 μM). ESI-05 inhibits cAMP-mediated activation of EPAC2, as well as EAPC2, mediated Rap1 activation. |
|
TP1376 |
GLP-1(7-37) acetate(106612-94-6 free base)
|
GLP-1(7-37) acetate |
Others
,
Glucagon Receptor
|
|
Glp-1(7-37) acetate is an intestinal insulin hormone that enhances glucose-induced insulin secretion. |
|
TP1382L |
HAEGTFTSDVS acetate
|
HAEGTFTSDVS acetate(864915-61-7 free base) |
Glucagon Receptor
|
|
HAEGTFTSDVS acetate is the first N-terminal 1-11 residues of GLP-1 which stimulates insulin secretion from pancreatic β-cells. |
|
TP2017L |
GIP (1-39) acetate
|
GIP (1-39) acetate(725474-97-5 Free base) |
Others
|
|
|
|
T31976 |
Glymidine sodium
|
|
Others
|
|
Glymidine sodium is a sulfonamide hypoglycemic agent which stimulates insulin secretion. |
|
T3984 |
GLP-1(7-36), amide
|
MKC 253,Human GLP-1-(7-36)-amide,Glucagon-like Peptide 1 (7-36) amide,Glucagon-Like Peptide (GLP) I (7-36), amide, human,GLP-1(7-36),GLP-1-(7-36)-amide |
Glucagon Receptor
|
|
GLP-1(7-36), amide (MKC 253) is a peptide hormone released from intestinal L-cells upon nutrient consumption. It binds the GLP-1 receptor in the pancreas and displays various antidiabetic effects by potentiating glucose-... |
|
TP1863L |
Glucagon (19-29), human acetate
|
|
Glucagon Receptor
|
|
Glucagon (19-29), human acetate a COOH-terminal fragment processed from glucagon, is a potent and efficient inhibitor of insulin secretion. |
|
TP2018L |
GIP (human) acetate
|
GIP (human) acetate(100040-31-1 Free base) |
IGF-1R
|
|
GIP (human) acetate is a stimulator of glucose-dependent insulin secretion and a weak inhibitor of gastric acid secretion. GIP (human) acetate plays a vital role in lipid metabolism and the development of obesity. |
|
T6646 |
Rosiglitazone hydrochloride
|
BRL-49653 HCl,Rosiglitazone HCl |
Ferroptosis
,
TRP/TRPV Channel
,
PPAR
,
Autophagy
|
|
Rosiglitazone hydrochloride (BRL-49653 HCl) is a blood glucose-lowering drugs, stimulating insulin secretion by binding to the PPAR receptors in fat cells. |
|
T6587 |
Mitiglinide Calcium
|
KAD-1229,S21403 |
ATPase
,
Potassium Channel
|
|
Mitiglinide Calcium (KAD-1229) is a blood glucose-lowering drugs, stimulating insulin secretion by closing the ATP-sensitive K+ channels in pancreatic beta-cells. |
|
T1781 |
GW9508
|
GW 9508 |
GPR
,
Potassium Channel
|
|
GW9508(GW 9508) is a potent and selective agonist for FFA1 (GPR40), stimulates insulin secretion in a glucose-sensitive manner. |
|
T1088 |
Repaglinide
|
AG-EE 388 ZW,AG-EE 623ZW |
Potassium Channel
,
PPAR
|
|
Repaglinide (AG-EE 623ZW) is a benzoic acid derivative that stimulates insulin secretion from the pancreas and is used in the therapy of type 2 diabetes. Repaglinide has been linked to rare instances of clinically appare... |
|
T13867 |
RH01386
|
|
Others
|
|
RH01386 is a small molecule that can prevent ER stress-induced β cell dysfunction and death, and inhibits proapoptotic gene expression,has the potential for type 2 diabetes treatment. RH01386 restores ER stress-impaired ... |
|
T37588L |
GIP (1-30) amide, porcine acetate
|
|
IGF-1R
|
|
GIP (1-30) amide, porcine acetate is an agonist of fully glucose-dependent insulinotropic polypeptide (GIP) receptor. GIP (1-30) amide, porcine acetate can weakly inhibit gastric acid secretion and strongly stimulate ins... |
|
T17177 |
TUG-424
|
TUG424 |
Others
|
|
TUG-424 significantly enhances glucose-stimulated insulin secretion at 100 nM. TUG-424 is a potent and selective free fatty acid receptor 1 agonist (EC50: 32 nM). |
|
T1674 |
Nateglinide
|
A4166,Senaglinide |
Potassium Channel
,
Proteasome
,
PPAR
|
|
Nateglinide (Senaglinide) is an oral hypoglycemic agent and amino acid derivative that stimulates insulin secretion from the pancreas and is used in the therapy of type 2 diabetes. Nateglinide has been linked to rare ins... |
|
T78097L |
Mazdutide acetate（2259884-03-0 free base）
|
Mazdutide acetate（2259884-03-0 free base）,OXM-3 acetate,LY-3305677 acetate,IBI-362 acetate |
Glucagon Receptor
|
|
Mazdutide acetate is a potent co-agonist of glucagon-like peptide (GLP-1R) and glucagon receptor (GCGR), a gastrin-regulating hormone analog.Mazdutide acetate stimulates insulin secretion from mouse pancreatic islets, an... |
|
T1530 |
Mitiglinide calcium hydrate
|
KAD-1229 calcium hydrate,Mitiglinide calcium,S-21403 calcium hydrate |
Potassium Channel
|
|
Mitiglinide calcium hydrate (S-21403 calcium hydrate) is a drug for the treatment of type 2 diabetes. Mitiglinide is thought to stimulate insulin secretion by closing the ATP-sensitive K(+) K(ATP) channels in pancreatic ... |
|
T15368L |
Galantide acetate
|
Galantide acetate(138579-66-5 Free base) |
Neuropeptide Y Receptor
|
|
Galantide acetate, a non-specific galanin receptor antagonist, is a peptide consisting of fragments of galanin and substance P. Galantide acetate recognizes two classes of galanin binding sites (KD<0.1 nM and ~6 nM) in t... |
|
T34470 |
S 9871
|
RX-801080,RX 801080,S9871,RX801080,S-9871 |
|
|
S 9871, also known as RX 801080, is an imidazoline derivative reported to antagonize imidazoline-stimulated insulin secretion. |
|
TP1141 |
GLP-1(7-36), amide acetate
|
GLP-1(7-36) Acetate,Human GLP-1-(7-36)-amide Acetate |
|
|
GLP-1(7-36) Acetate is a major intestinal hormone that stimulates glucose-induced insulin secretion from β cells. |
|
T70373 |
AS2575959
|
|
|
|
AS2575959 is a novel GPR40 agonist, exhibiting glucose metabolism improvement and synergistic effect with sitagliptin on insulin and incretin secretion. |
|
T70113 |
ATM-1001
|
|
|
|
ATM-1001 is an inhibitor of the cancer-associated tropomyosin 3.1 (Tpm3.1), suppressing glucose-stimulated insulin secretion (GSIS) from the pancreatic islets. |
|
TP2258 |
HNGF6A
|
|
Others
|
|
increases glucose stimulated insulin secretion and glucose metabolism |
|
T37892 |
GLP-1(7-36), amide TFA
|
|
|
|
GLP-1(7-36), amide TFA is a prominent intestinal hormone known to stimulate glucose-induced insulin secretion from β cells[1]. |
|
T62836 |
Hit 1
|
|
|
|
Hit 1 is an activator of insulin-degrading enzymes (IDE) (EC50: 5.5 μM) and reduces glucose-stimulated insulin secretion. |
|
TP2209 |
Xenin-8
|
|
Others
|
|
neurotensin-like peptide that modulate pancreatic insulin and glucagon secretion/effects |
|
T40518 |
C-Peptide 2, rat
|
|
|
|
C-Peptide 2, rat, a 31-amino-acid peptide, serves as a constituent in proinsulin. It possesses the ability to hinder glucose-triggered insulin secretion. |
|
T71251 |
DS-1558
|
|
|
|
DS-1558 is a potent and orally available GPR40 agonist.DS-1558 was found to have potent glucose lowering effects during an oral glucose tolerance test in ZDF rats. DS-1558 significantly and dose-dependently improved hyp... |
|
T27938 |
LY2922083
|
LY 2922083,LY-2922083 |
|
|
LY2922083 is a Potent and Selective GPR40 agonist. LY2922083 demonstrates potent, efficacious and durable dose dependent reductions in glucose levels along with significant increases in insulin and GLP-1 secretion. |
|
T25739 |
Linogliride
|
McN-3935,McN3935,McN 3935,Linogliridum,Linoglirida |
|
|
Linogliride is a guanidine-based inhibitor of insulin secretion and a structural analog of pirogliride with hypoglycemic activity. It blocks ATP-sensitive potassium channels in the pancreatic beta cell membrane, thereby ... |
|
T25739L |
Linogliride fumarate
|
McN 3935,McN-3935,McN3935 |
|
|
Linogliride fumarate is the fumarate salt of Linogliride. Linogliride is a guanidine-based inhibitor of insulin secretion and a structural analog of pirogliride with hypoglycemic activity. It blocks ATP-sensitive potassi... |
|
TP1584 |
GIP (1-30) amide,human
|
GIP (1-30) amide (Human) |
|
|
GIP (1-30) amide (Human) is an insulin-dependent glucose-dependent polypeptide.The sugar-dependent insulin polypeptide (GIP) is an insulin secreting hormone, which can stimulate the secretion of insulin and reduce the oc... |
|
T40697 |
Glucocorticoids receptor agonist 2
|
|
|
|
Glucocorticoid receptor agonist 2 is a highly effective anti-inflammatory compound, derived from arylpyrazole, that actively binds to and activates the glucocorticoid receptor. This compound exhibits potent anti-inflamma... |
|
T40808 |
Glucocorticoids receptor agonist 1
|
|
|
|
Glucocorticoids receptor agonist 1 (GRA-1) is a highly effective arylpyrazole-based compound that acts as an agonist for the glucocorticoid receptor. GRA-1 exhibits strong anti-inflammatory properties while maintaining i... |
|
T24620 |
PF-06372222
|
PF-0637222,PF0637222,PF 0637222 |
|
|
PF-06372222 is a small-molecule negative allosteric modulator of the glucagon receptor (GCGR). PF-06372222 is also an antagonist for glucagon-like peptide-1 receptor GLP-1R, which inhibits glucagon secretion and glucose... |
|
TP1630 |
A-71915 TFA (132956-87-7 free base)
|
A-71915 TFA |
|
|
A-71915 (TFA) is a selective inhibitor of ANP receptor (atrial natriuretic peptide-receptor), induces apoptosis and decreases insulin secretion in RINm5F pancreatic β-cells. |
|
TP1241 |
Adrenocorticotropic Hormone (ACTH) (18-39), human
|
ACTH (18-39), human |
|
|
Adrenocorticotropic Hormone (ACTH) (18-39) is known as the Corticotropin-like Intermediate Lobe Peptide. It stimulates insulin secretion as well as amylase and protein secretion in a dose-dependent manner similar to thos... |
|
T76041 |
GIP (1-30) amide,human acetate
|
|
|
|
GIP (1-30) amide, human acetate is a fragment of glucose-dependent insulinotropic polypeptide (GIP), an incretin hormone that plays a crucial role in stimulating insulin secretion and mitigating postprandial glycemic exc... |
|
T69477 |
F81-1144b
|
|
|
|
F81-1144b is a matrix metalloproteinase inhibitor which reduces secretion of very low density lipoprotein-triacylglycerol, thereby lowering TAG levels in serum and the liver. F81-1144b also lowers VLDL-TAG secretion, de ... |
|
T71020 |
PF-04671536
|
|
|
|
PF-04671536 is a highly potent and selective inhibitor of phosphodiesterase 8B (PDE8B) phosphodiesterase 8A (PDE8A). In primary human pancreatic islets, PF-04671536 increases insulin secretion in a glucose-dependent mann... |
|
T69380 |
Cinnamic acid, hydrazide
|
|
|
|
Cinnamic acid, hydrazide is an unsaturated carboxylic acid and precursor to aspartame via enzyme-catalysed amination to phenylalanine. Cinnamic acid may be useful in prevention or treatment of Diabetes through various me... |
|
TP2017 |
GIP (1-39)
|
|
|
|
Endogenous truncated form of the incretin hormone GIP. More potent at stimulating glucose-dependent insulin secretion from rat pancreatic β-cells than GIP. |
|
T80149 |
GRPP (human)
|
|
|
|
GRPP (human), a 30-amino-acid peptide derived from Gcg, modestly elevates plasma insulin levels while reducing plasma glucagon concentrations. However, GRPP (human) has no impact on insulin secretion within rat islets [1... |
|
TP1566 |
GIP (1-30) amide (Human) (TFA)
|
|
|
|
GIP (1-30) amide (Human) TFA is a glucose-dependent insulinotropic polypeptide fragment. Glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone that stimulates insulin secretion and reduces postprandia... |
